Recombinant Human IL-15 Protein
Catalugue Number: GW-TL202-0050
GW-TL202-0100
GW-TL202-1000（Customize）
Filling Volume: 50μg、100μg、1mg
Stock: In Stock
Product Information
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Cytokines-Recombinant Human IL-15 Protein |
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| Product Name | Recombinant Human IL-15 Protein |
| Expression Host | HEK293 cells |
| QC Testing Purity | >95% as determined by SDS-PAGE |
| Activity | The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be 0.2~3ng/mL. The specific activity of recombinant human IL-15 is > 5×10⁶ IU/mg, which is calibrated against the human IL-15 WHO International Standard (NIBSC code:95/554). |
| Endotoxin | < 0.01EU per μg of the protein as determined by the LAL method. |
| Molecular Mass | The recombinant human IL-15 predicts a molecular mass of 12.8 kD and 33kD. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization. |
| Stability & Storage |
Lyophilized preparation can be stored at -20 ℃. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution. Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS. Avoid repeated freeze-thaw cycles. |
| Background | The protein encoded by IL-15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that IL-15 may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. |
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